|
Symbol: NTH1 Name: Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p Entrez gene ID: 851564 Species: Yeast (Taxid: 4932) Functional description: Nth1p; Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p [Source:SGD;Acc:S000002408] [Ensembl] Observation: Deletion of NTH1 decreases mean replicative lifespan by 15% in the a strain [19030232] and mean chronological lifespan by 30% (at 30 degree Celsus in BY4742) [22783207]. Mutant NTH1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. NTH1 mutant cells have elevated trehalose concentration and reduced oxidative carbonylation of cellular proteins before they enter the non-proliferative stationary growth phase which remained high during the stationary phase [22783207]. Interventions: Assays: Replicative Lifespan Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit