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Symbol: akt-1 Name: AKT kinase family 1 Alias: akt-1a; akt-1b Entrez gene ID: 179424 Ensembl gene ID: C12D8.10 Species: Worm (Taxid: 6239) Functional description: Acts downstream of age-1 and pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead- related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. [UniProt] Observation: RNA interference of akt-1 leads to lifespan extension [15998808]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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