Figure 5. miR-239 and miR-71 Function through the IGF-1/Insulin-like and the DNA Damage Checkpoint Pathways

Study: MicroRNAs both promote and antagonize longevity in C. elegans.
Species: Nematode
Assay: Organismal
Data: genotype treatment mean max
#temperature=20
#strain=N2

wt - 18 23
mir-239(nDf62) - 20 27
wt daf-16(RNAi) 13 19
mir-239(nDf62) daf-16(RNAi) 13 18
wt daf-2(RNAi) 29 34
mir-239(nDf62) daf-2(RNAi) 26 33

wt - 19 28
mir-71(n4115) - 9 15
wt daf-2(RNAi) 33 40
mir-71(n4115) - 13 21

wt - 20 24
mir-71(n4115) - 10 14
wt daf-16(RNAi) 14 19
mir-71(n4115) daf-16(RNAi) 10 13

wt - 20 24
mir-71(n4115) - 10 14
wt cdc-25.1(RNAi) 22 27
mir-71(n4115) cdc-25.1(RNAi) 11 14
Measurments:
  • wild-type_20_18_23
  • mir-239(nDf62)_20_20_27
  • wild-type_daf-16(RNAi)_20_13_19
  • mir-239(nDf62)_daf-16(RNAi)_20_13_18
  • wild-type_daf-2(RNAi)_20_29_34
  • mir-239(nDf62)_daf-2(RNAi)_20_26_33
  • wild-type_20_19_28
  • mir-71(n4115)_20_9_15
  • wild-type_daf-2(RNAi)_20_33_40
  • mir-71(n4115)_20_13_21
  • wild-type_20_20_24
  • mir-71(n4115)_20_10_14
  • wild-type_daf-16(RNAi)_20_14_19
  • mir-71(n4115)_daf-16(RNAi)_20_10_13
  • wild-type_20_20_24
  • mir-71(n4115)_20_10_14
  • wild-type_cdc-25.1(RNAi)_20_22_27
  • mir-71(n4115)_cdc-25.1(RNAi)_20_11_14
  • Comparisons:
  • mir-239(nDf62) vs. wild-type
  • wild-type RNAi vs. wild-type
  • mir-239(nDf62) RNAi vs. wild-type
  • wild-type RNAi vs. wild-type
  • mir-239(nDf62) RNAi vs. wild-type
  • mir-71(n4115) vs. wild-type
  • wild-type RNAi vs. wild-type
  • mir-71(n4115) vs. wild-type
  • mir-71(n4115) vs. wild-type
  • wild-type RNAi vs. wild-type
  • mir-71(n4115) RNAi vs. wild-type
  • mir-71(n4115) vs. wild-type
  • wild-type RNAi vs. wild-type
  • mir-71(n4115) RNAi vs. wild-type

  • ID exp ctr Manipulation intervention mean median max pvalue T Gender epistasis
    311 wild-type_daf-16(RNAi)_20_13_19 wild-type_20_18_23 RNAi daf-16 RNAi -27.7777777778 -17.3913043478 20°C
    321 mir-71(n4115)_20_10_14 wild-type_20_20_24 - mir-71 mutation -50.0 -41.6666666667 20°C
    318 mir-71(n4115)_20_10_14 wild-type_20_20_24 - mir-71 mutation -50.0 -41.6666666667 20°C
    315 mir-71(n4115)_20_9_15 wild-type_20_19_28 - mir-71 mutation -52.6315789474 -46.4285714286 20°C
    312 mir-239(nDf62)_daf-16(RNAi)_20_13_18 wild-type_20_18_23 RNAi mir-239 mutation -27.7777777778 -21.7391304348 20°C
    322 wild-type_cdc-25.1(RNAi)_20_22_27 wild-type_20_20_24 RNAi cdc-25.1 RNAi 10.0 12.5 20°C
    319 wild-type_daf-16(RNAi)_20_14_19 wild-type_20_20_24 RNAi daf-16 RNAi -30.0 -20.8333333333 20°C
    316 wild-type_daf-2(RNAi)_20_33_40 wild-type_20_19_28 RNAi daf-2 RNAi 73.6842105263 42.8571428571 20°C
    313 wild-type_daf-2(RNAi)_20_29_34 wild-type_20_18_23 RNAi daf-2 RNAi 61.1111111111 47.8260869565 20°C
    310 mir-239(nDf62)_20_20_27 wild-type_20_18_23 - mir-239 mutation 11.1111111111 17.3913043478 20°C
    323 mir-71(n4115)_cdc-25.1(RNAi)_20_11_14 wild-type_20_20_24 RNAi mir-71 mutation -45.0 -41.6666666667 20°C
    320 mir-71(n4115)_daf-16(RNAi)_20_10_13 wild-type_20_20_24 RNAi mir-71 mutation -50.0 -45.8333333333 20°C
    317 mir-71(n4115)_20_13_21 wild-type_20_19_28 - mir-71 mutation -31.5789473684 -25.0 20°C
    314 mir-239(nDf62)_daf-2(RNAi)_20_26_33 wild-type_20_18_23 RNAi mir-239 mutation 44.4444444444 43.4782608696 20°C
    • 14 comparisons

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