Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves

Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Assay: RLS
Data: genotype mean median max pvalue pvalue pvalue
#temperature=30

wt 23.7 23 60 80 - - -
mrpl23 28.2 28 51 60 6.82E-03 - -

wt 25.8 24 53 60 - - -
yta12 20.0 20 41 53 5.45E-03 - -

wt 26.7 26 57 160 - - -
rho0 26.1 26 50 160 9.41E-01 - -
afg3 30.7 31 43 20 3.71E-02 5.25E-02 -
afg3;rho0 30.3 32 59 40 3.00E-02 7.74E-02 9.94E-01

W303 18.8 20 36 40 - - -
W303;afg3 19.6 21 36 80 6.87E-01 - -

# MLS of rho0 and some other are guessed.
Measurments:
  • wild-type_30_23_23_60
  • mrpl23_30_28_28_51
  • wild-type_30_25_24_53
  • yta12_30_20_20_41
  • wild-type_30_26_26_57
  • rho0_30_26_26_50
  • afg3_30_30_31_43
  • afg3;rho0_30_30_32_59
  • W303_30_18_20_36
  • W303;afg3_30_19_21_36
  • Comparisons:
  • mrpl23 vs. wild-type
  • yta12 vs. wild-type
  • rho0 vs. wild-type
  • afg3 vs. wild-type
  • afg3;rho0 vs. wild-type
  • W303;afg3 vs. W303

  • ID exp ctr Manipulation intervention mean median max pvalue T Gender epistasis
    115 rho0_30_26_26_50 wild-type_30_26_26_57 - -2.24719101124 -12.2807017544 30°C
    114 yta12_30_20_20_41 wild-type_30_25_24_53 - -22.480620155 -16.6666666667 -22.641509434 30°C
    118 W303;afg3_30_19_21_36 W303_30_18_20_36 - 4.25531914894 5.0 30°C
    116 afg3_30_30_31_43 wild-type_30_26_26_57 - AFG3 deletion 14.9812734082 19.2307692308 -24.5614035088 0.0525 30°C
    113 mrpl23_30_28_28_51 wild-type_30_23_23_60 - 18.9873417722 21.7391304348 -15.0 30°C
    117 afg3;rho0_30_30_32_59 wild-type_30_26_26_57 - 13.4831460674 23.0769230769 3.50877192982 0.0774 30°C
    • 6 comparisons

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