Figure 5: Hac1-independent resistance to tunicamycin in afg3∆ and rpl20bΔ cells

Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Assay: RLS
Data: genotype mean median max num pvalue pvalue pvalue
#temperature=30

wt 23.2 24 38 40 - - -
afg3 28.4 28 56 160 2.04E-03 - -
hac1 25.6 26 40 20 3.22E-01 2.15E-0.1 -
afg3;hac1 30.7 32 50 40 2.08E-04 1.16E-01 3.49E-02

# Note: afg3;hac1 max LS is guessed.
Measurments:
  • wild-type_30_23_24_38_40
  • afg3_30_28_28_56_160
  • hac1_30_25_26_40_20
  • afg3;hac1_30_30_32_50_40
  • Comparisons:
  • afg3 vs. wild-type
  • hac1 vs. wild-type
  • afg3;hac1 vs. wild-type

  • ID exp ctr Manipulation intervention mean median max pvalue T Gender epistasis
    122 afg3_30_28_28_56_160 wild-type_30_23_24_38_40 - AFG3 deletion 22.4137931034 16.6666666667 47.3684210526 30°C
    123 hac1_30_25_26_40_20 wild-type_30_23_24_38_40 - HAC1 deletion 10.3448275862 8.33333333333 5.26315789474 30°C
    124 afg3;hac1_30_30_32_50_40 wild-type_30_23_24_38_40 - 32.3275862069 33.3333333333 31.5789473684 0.0349 30°C
    • 3 comparisons

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