|in situ Regeneration ||1 ||2 ||Wuttke; Zamani ||
:Abstract: As we are young everything regenerates perfectly. In fact, our body harbors the plan to reconstruct itself from scratch which is localized in the nucleus of each of our body cells. However, as we grow up our regenerative capacities decre... |
|Long-Lived Species ||1 ||8 ||Hudson; Penzias; Lee; Lee; Lee; Johnson; Hsu; Dodd ||
:Abstract: Wonders of extraordinary long-lived species - will they ever end? Species adapted to their environments with a specific lifespan. Most species developed aging to speed up their evolution. Non-aging species normally would be out-compete... |
|Circadian Clock Controls Ageing ||2 ||3 ||Magalhaes; Wuttke; Wood ||
:Abstract: Dietary restriction without malnutrition delays ageing and extends lifespan, but the molecular mechanism is still unknown. Ageing gene expression changes originate from development and growth cessation, are modulated by diet, and manip... |
|Denigma ||5 ||9 ||Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall ||Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
|Tissue-Specific DR-Effects ||2 ||4 ||Kapahi; Magalhaes; Wuttke; Li ||
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
|miRNAs Control Aging ||3 ||8 ||Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson ||
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
|Aging Reprogramming ||0 ||3 ||Stolzing; Wuttke; Johnson ||
:Abstract: Ectopic expression of defined pluripotence-associated Factors reprograms adult somatic cells back to an Embryonic Stem Cell-like state. During this process the phenoytpic characteristics of Aging are also reverted. Cells can even be di... |
|Circadian Rhythm ||2 ||4 ||Kapahi; Magalhaes; Wuttke; Katewa ||Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker .
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
|Continuous Longevity Meeting ||3 ||4 ||Debonneuil; Wuttke; Singh; Maidano ||The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
|Pentose Phosphate Pathway ||2 ||3 ||Magalhaes; Wuttke; Tang ||The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
|Collaborative Knowledge-Management ||1 ||2 ||Kulaga; Wuttke ||We will establish **new kind of collaboration models** between people (including Researches) and in **Graph representation of knowledge**.
``Collaboration and knowledge-management websystems`` are the clue that **increases collective intelligence*... |
|Wikipedia ||1 ||2 ||Turchin; Maidano ||Wikipedia is the biggest free online encyclopedia.
In order to increase public awareness, there shall be Wikipedia articles about the International Longevity Alliance and its associated Projects like Denigma. ... |
|Longevity Day ||1 ||1 ||Stambler ||A specific day shall be defined as **official longevity day** (1. of March, the *Future Day* appears to be most suitable). This day, the ``Day of Concerted Longevity Activism`` functions to ``awake global awareness`` on the ``Research on longevity`` ... |
|Lobbying ||1 ||4 ||Stambler; Khaltourina; Coernette; AgeVivo ||Lobbying is the act of **attempting to influence decisions** made by officials in the government, most often legislators or members of the regular agencies. For effective lobbying it is crucial to first ``set goals and objectives``. Actions for the n... |
|Longevity Media ||1 ||4 ||Katiyar; Xu; Coernette; Maidano ||Longevity and the problem of Aging should be broadcasted via different media. For instance a **Longevity radio** and/or **online TV channel** shall be established, which functions several purposes:
* Making people **aware of** the possibility of *... |
|Curing Cancer ||1 ||3 ||Coles; Debonneuil; Stambler ||**Cancer** is ``function of Aging`` and its ``elimination is necessary`` for achieving longevity. Different **experimental approaches** can highly effectively **cure** or at least regress defined types of **Cancers**.
``Dr. Stephen Coles`` is an i... |
|Age In Vivo ||2 ||7 ||Kulaga; Wuttke; AgeVivo; Logic; Mind; cryonicsculture; Horusavatar ||*in vivo* (Latin for ``within living``) is experimentations that **utilizes whole living organisms**.
Age *in vivo* is ``do it yourself`` **Biology on Aging**. The goal is to bring in more people interested in Aging. Hence, it is primarily of prom... |
|Health Extension Media Responses And Outreach ||1 ||2 ||Xu; Pellissier ||``Analyse`` and ``systemize`` **Health/Longevity Media Responses**. We need to keep track of the information that is broadcasted to the public and guarantee that it is positively interpreted and understood. Create a **portal** that Links in all the d... |
|Educational Platform ||1 ||4 ||Stambler; Kulaga; Katiyar; Xu ||``Eduction`` should be **free to anyone**. The International Longevity Alliance promotes eduction of people about longevity.
Classic Universities shall offer **Anti-Aging related courses**.
Further, something along the line of **Longevity Unive... |
|Crowd Funding ||1 ||4 ||Kulaga; Khaltourina; Katiyar; Xu ||Crowd funding/financing is the collaborative effort of individuals who network and **pool** their **money** usually via Internet **to support** the **effort of a group/organization**.
It therefore provides a powerful **alternative resource to gran... |
|Materials in Different Languages ||1 ||2 ||Turchin; Coernette ||Content on promoting longevity written/spoken/rendered in one language should be translated and promoted into other languages. A priority is to have at least ``English versions`` of everything. Optionally possibilities to translate into other local ... |
|Newsletter ||1 ||1 ||Silvennoinen ||A Newsletter is a regularly/periodically distributed/sent publication about a particular topic that is of interest to the subscribers.
The International Longevity Alliance has already implemented an Email registration option to receive Email updat... |
|Health Information ||1 ||2 ||Debonneuil; Stambler ||There is a need to ``collect data on people's health`` and try to **analyze it in relation to aging**, longevity and optimal life style.
There shall be a ``open database system`` that includes **clinical information** on patients most importantly ... |
|Encouraging Initiative ||1 ||2 ||Wuttke; Coernette ||A merit earning system build on top of the Achievements, that gives Researchers, Developers and Artists as well as other people the recognition and respect for their contribution and work need to be established. Such a system that awards merit for go... |
|Grant Writing ||1 ||2 ||Debonneuil; Stambler ||Grant writing is the practice of ``completing an application process for funding`` provided by institution like government department, corporation, foundation or trust.
In the name of the International Longevity Alliance there shall be **assistanc... |