| Aging Reprogramming | 0 | 3 | Stolzing; Wuttke; Johnson |
:Abstract: Ectopic expression of defined pluripotence-associated Factors reprograms adult somatic cells back to an Embryonic Stem Cell-like state. During this process the phenoytpic characteristics of Aging are also reverted. Cells can even be di... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Longevity Variant Database | 3 | 6 | Schaum; Wuttke; Adams; Betts-Lacroix; Juan; Fortney | ##########################
Longevity Variant Database
##########################
:Journal: Nucleic Acid Research
:Deadline: 25th August 2013
:Abstract: We are constructing the most comprehensive database on genetic variants associated with longe... |
| miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
| Continuous Longevity Meeting | 3 | 4 | Debonneuil; Wuttke; Singh; Maidano | The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
| Longevity Variant Database | 3 | 6 | Schaum; Wuttke; Adams; Betts-Lacroix; Juan; Fortney | ##########################
Longevity Variant Database
##########################
:Journal: Nucleic Acid Research
:Deadline: 25th August 2013
:Abstract: We are constructing the most comprehensive database on genetic variants associated with longe... |
| Human Experimental Aging Biology | 2 | 3 | Debonneuil; Wuttke; Watson | The system of clinical trials in Western countries has been bogged down by high costs, red tape, and governmental restrictions to the point that within 10 years the engine of innovation in biotechnology will die [22378269].
In order to prevent thi... |
| Non-Programmed Aging Hypotheses | 1 | 2 | Wuttke; Libertini | ###############################
Non-Programmed Aging Hypotheses
###############################
=========================================
Tenable Scientific Theories or old Dogmas
=========================================
:Abstract: Knowing t... |
| Information Theory | 2 | 3 | Stambler; Wuttke; Blokh | Information theory is a field of applied mathematics, engineering and computer science that measures information.
It originates from the finding of the fundamental limits on signal processing operations, such as compressing data, and on reliable s... |
| Global Computing Initiative | 1 | 5 | Kulaga; Wuttke; Borisoglebsky; Brown; Bartko | | **Global** GCI
| **Computing**
| **Initiative**
The Global Computing Initiative (GCI) are Developers dedicated in the development of computational technologies that facilitate the advancement of human collective knowledge and support anti-Agin... |
| Graph Visualization | 3 | 7 | Stambler; Kulaga; Wuttke; Nishry; Mind; Atraylen; Horusavatar | **Data on Aging** need to be **visualized** with an ``interactive`` and ``intuitive interface`` that enables ``collaborative reverse-engineering`` of the Aging process. It shall be a popular and interactive way of to convey a basic understanding of t... |
| Semantic Web Against Aging | 1 | 7 | Kulaga; Medvedev; Wuttke; Repnikov; Borisoglebsky; Orlovs; Zimin |
.. contents:: **Contents**
Authors : Daniel Wutske (Hevok), Anton Kulaga (antonkulaga), Dmitry Borisoglebsky
Preface
=======
Let us start from the original description of Denigma Project and then move forward.
“By integrating all... |
| miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
| Circadian Clock Controls Ageing | 2 | 3 | Magalhaes; Wuttke; Wood |
:Abstract: Dietary restriction without malnutrition delays ageing and extends lifespan, but the molecular mechanism is still unknown. Ageing gene expression changes originate from development and growth cessation, are modulated by diet, and manip... |
| Microarray Game | 3 | 3 | Shytikov; Wuttke; Tang | There are many possibilities to analyze molecular Signatures. They can be compared to each other, meta-signature via Meta-Analysis can be derived, functional enriched terms can be assessed as well as Lifespan Factors identified.
It is possible to ... |
| Continuous Longevity Meeting | 3 | 4 | Debonneuil; Wuttke; Singh; Maidano | The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Longevity Variant Database | 3 | 6 | Schaum; Wuttke; Adams; Betts-Lacroix; Juan; Fortney | ##########################
Longevity Variant Database
##########################
:Journal: Nucleic Acid Research
:Deadline: 25th August 2013
:Abstract: We are constructing the most comprehensive database on genetic variants associated with longe... |
| Microarray Game | 3 | 3 | Shytikov; Wuttke; Tang | There are many possibilities to analyze molecular Signatures. They can be compared to each other, meta-signature via Meta-Analysis can be derived, functional enriched terms can be assessed as well as Lifespan Factors identified.
It is possible to ... |
| Pentose Phosphate Pathway | 2 | 3 | Magalhaes; Wuttke; Tang | The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
... |
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