| Pentose Phosphate Pathway | 2 | 3 | Magalhaes; Wuttke; Tang | The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
... |
| Microarray Game | 3 | 3 | Shytikov; Wuttke; Tang | There are many possibilities to analyze molecular Signatures. They can be compared to each other, meta-signature via Meta-Analysis can be derived, functional enriched terms can be assessed as well as Lifespan Factors identified.
It is possible to ... |
| miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Graph Visualization | 3 | 7 | Stambler; Kulaga; Wuttke; Nishry; Mind; Atraylen; Horusavatar | **Data on Aging** need to be **visualized** with an ``interactive`` and ``intuitive interface`` that enables ``collaborative reverse-engineering`` of the Aging process. It shall be a popular and interactive way of to convey a basic understanding of t... |
| Age In Vivo | 2 | 7 | Kulaga; Wuttke; AgeVivo; Logic; Mind; cryonicsculture; Horusavatar | *in vivo* (Latin for ``within living``) is experimentations that **utilizes whole living organisms**.
Age *in vivo* is ``do it yourself`` **Biology on Aging**. The goal is to bring in more people interested in Aging. Hence, it is primarily of prom... |
| Circadian Rhythm | 2 | 4 | Kapahi; Magalhaes; Wuttke; Katewa | Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
| Tissue-Specific DR-Effects | 2 | 4 | Kapahi; Magalhaes; Wuttke; Li |
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
| Continuous Longevity Meeting | 3 | 4 | Debonneuil; Wuttke; Singh; Maidano | The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
| Materials in Different Languages | 1 | 2 | Turchin; Coernette | Content on promoting longevity written/spoken/rendered in one language should be translated and promoted into other languages. A priority is to have at least ``English versions`` of everything. Optionally possibilities to translate into other local ... |
| Human Experimental Aging Biology | 2 | 3 | Debonneuil; Wuttke; Watson | The system of clinical trials in Western countries has been bogged down by high costs, red tape, and governmental restrictions to the point that within 10 years the engine of innovation in biotechnology will die [22378269].
In order to prevent thi... |
| Collaborative Knowledge-Management | 1 | 2 | Kulaga; Wuttke | We will establish **new kind of collaboration models** between people (including Researches) and in **Graph representation of knowledge**.
``Collaboration and knowledge-management websystems`` are the clue that **increases collective intelligence*... |
| Logo Contest | 1 | 3 | Silvennoinen; Flatt; Maidano | The individual **longevity parties** operate under the ``banner`` of the International Longevity Alliance (**ILA**). However, the ILA does not yet have such an unifying banner.
The logo will be utilized **cross-nationally** with only minor modific... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Curing Cancer | 1 | 3 | Coles; Debonneuil; Stambler | **Cancer** is ``function of Aging`` and its ``elimination is necessary`` for achieving longevity. Different **experimental approaches** can highly effectively **cure** or at least regress defined types of **Cancers**.
``Dr. Stephen Coles`` is an i... |
| Crowd Funding | 1 | 4 | Kulaga; Khaltourina; Katiyar; Xu | Crowd funding/financing is the collaborative effort of individuals who network and **pool** their **money** usually via Internet **to support** the **effort of a group/organization**.
It therefore provides a powerful **alternative resource to gran... |
| Grant Writing | 1 | 2 | Debonneuil; Stambler | Grant writing is the practice of ``completing an application process for funding`` provided by institution like government department, corporation, foundation or trust.
In the name of the International Longevity Alliance there shall be **assistanc... |
| Longevity Media | 1 | 4 | Katiyar; Xu; Coernette; Maidano | Longevity and the problem of Aging should be broadcasted via different media. For instance a **Longevity radio** and/or **online TV channel** shall be established, which functions several purposes:
* Making people **aware of** the possibility of *... |
| Educational Platform | 1 | 4 | Stambler; Kulaga; Katiyar; Xu | ``Eduction`` should be **free to anyone**. The International Longevity Alliance promotes eduction of people about longevity.
Classic Universities shall offer **Anti-Aging related courses**.
Further, something along the line of **Longevity Unive... |
| Encouraging Initiative | 1 | 2 | Wuttke; Coernette | A merit earning system build on top of the Achievements, that gives Researchers, Developers and Artists as well as other people the recognition and respect for their contribution and work need to be established. Such a system that awards merit for go... |
| Lobbying | 1 | 4 | Stambler; Khaltourina; Coernette; AgeVivo | Lobbying is the act of **attempting to influence decisions** made by officials in the government, most often legislators or members of the regular agencies. For effective lobbying it is crucial to first ``set goals and objectives``. Actions for the n... |
| Information Theory | 2 | 3 | Stambler; Wuttke; Blokh | Information theory is a field of applied mathematics, engineering and computer science that measures information.
It originates from the finding of the fundamental limits on signal processing operations, such as compressing data, and on reliable s... |
| Health Extension Media Responses And Outreach | 1 | 2 | Xu; Pellissier | ``Analyse`` and ``systemize`` **Health/Longevity Media Responses**. We need to keep track of the information that is broadcasted to the public and guarantee that it is positively interpreted and understood. Create a **portal** that Links in all the d... |
| Graph Visualization | 3 | 7 | Stambler; Kulaga; Wuttke; Nishry; Mind; Atraylen; Horusavatar | **Data on Aging** need to be **visualized** with an ``interactive`` and ``intuitive interface`` that enables ``collaborative reverse-engineering`` of the Aging process. It shall be a popular and interactive way of to convey a basic understanding of t... |
| Health Information | 1 | 2 | Debonneuil; Stambler | There is a need to ``collect data on people's health`` and try to **analyze it in relation to aging**, longevity and optimal life style.
There shall be a ``open database system`` that includes **clinical information** on patients most importantly ... |
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