Authors: Kaeberlein M; Steffen KK; Hu D; Dang N; Kerr EO; Tsuchiya M; Fields S; Kennedy BK
Abstract: Calorie restriction (CR) increases life span in yeast independently of Sir2. Lamming et al. (Reports, 16 September 2005, p. 1861) recently proposed that Sir2-independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1.
Keywords: *Caloric Restriction; Glucose/metabolism; Histone Deacetylases/*physiology; *Longevity; Saccharomyces cerevisiae/*physiology; Saccharomyces cerevisiae Proteins/*physiology; Silent Information Regulator Proteins, Saccharomyces cerevisiae/*physiology; Sirtuin 2; Sirtuins/*physiology
Journal: Science (New York, N.Y.) Volume: 312 Issue: 5778 Pages: 1312; author reply 1312 Date: June 3, 2006 PMID: 16741098 |
Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, Fields S, Kennedy BK (2006) Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science (New York, N.Y.) 312: 1312; author reply 1312.
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