Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.

Authors: Mitsui A; Hamuro J; Nakamura H; Kondo N; Hirabayashi Y; Ishizaki-Koizumi S; Hirakawa T; Inoue T; Yodoi J

Abstract: Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.

Keywords: Animals; Bone Marrow Cells/metabolism/radiation effects; Brain/metabolism; Humans; *Longevity; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium/metabolism; *Oxidative Stress; Spleen/enzymology; Survival Rate; Telomerase/metabolism; Thioredoxins/*genetics/*metabolism; Ultraviolet Rays
Journal: Antioxidants & redox signaling
Volume: 4
Issue: 4
Pages: 693-6
Date: Sept. 17, 2002
PMID: 12230882
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Citation:

Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, Ishizaki-Koizumi S, Hirakawa T, Inoue T, Yodoi J (2002) Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxidants & redox signaling 4: 693-6.



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