Extended longevity in mice lacking the insulin receptor in adipose tissue.

Authors: Blüher M; Kahn BB; Kahn CR

Abstract: Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathways. To further explore these associations with enhanced longevity, we studied mice with a fat-specific insulin receptor knockout (FIRKO). These animals have reduced fat mass and are protected against age-related obesity and its subsequent metabolic abnormalities, although their food intake is normal. Both male and female FIRKO mice were found to have an increase in mean life-span of approximately 134 days (18%), with parallel increases in median and maximum life-spans. Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling.

Keywords: Adipose Tissue/*anatomy & histology/*metabolism; Aging; Animals; Body Constitution; Body Weight; Caloric Restriction; Eating; Female; Insulin/metabolism; Insulin-Like Growth Factor I/metabolism; *Longevity; Male; Mice; Mice, Knockout; Receptor, Insulin/*genetics/metabolism; Signal Transduction; *Thinness
Journal: Science (New York, N.Y.)
Volume: 299
Issue: 5606
Pages: 572-4
Date: Jan. 25, 2003
PMID: 12543978
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Blüher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (New York, N.Y.) 299: 572-4.

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