Authors: Orr WC; Sohal RS
Abstract: The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.Keywords: Aging/genetics/*physiology; Animals; Animals, Genetically Modified; Catalase/genetics/*metabolism; Drosophila melanogaster/enzymology/genetics/*physiology; Female; Gene Expression; Longevity; Male; Oxidation-Reduction; Oxygen Consumption; Proteins/metabolism; Reactive Oxygen Species/metabolism; Superoxide Dismutase/genetics/*metabolism
Journal: Science (New York, N.Y.)
Date: Feb. 25, 1994
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Orr WC, Sohal RS (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science (New York, N.Y.) 263: 1128-30.