Authors: Arum O; Bonkowski MS; Rocha JS; Bartke A
Abstract: The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric restriction, in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction, we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting diet. The intermittent fasting diet increased the survivorship and improved insulin sensitivity of normal males, but failed to affect either parameter in GHR-KO mice. From the results of two paradigms of dietary restriction, we postulate that GHR-KO mice would be resistant to any manner of dietary restriction; potentially due to their inability to further enhance insulin sensitivity. Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention.Keywords: Animals; Blood Glucose/metabolism; Body Weight; *Fasting; Female; *Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Somatotropin/deficiency/genetics/*metabolism; Sex Characteristics
Journal: Aging cell
Date: Sept. 15, 2009
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Arum O, Bonkowski MS, Rocha JS, Bartke A (2009) The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging cell 8: 756-60.