Authors: Wysocka J; Herr W
Abstract: When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - the POU-domain transcription factor Oct-1 and the cell-proliferation factor HCF-1 - to activate transcription of the first set of expressed viral genes. This regulatory complex, called the VP16-induced complex, reveals mechanisms of combinatorial control of transcription. The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host.Keywords: Animals; Cell Division; DNA-Binding Proteins/*metabolism; Gene Expression Regulation; Herpes Simplex Virus Protein Vmw65/chemistry/*physiology; Host Cell Factor C1; Octamer Transcription Factor-1; Proteins/*metabolism; Simplexvirus/*metabolism; Transcription Factors/*metabolism; *Transcription, Genetic
Journal: Trends in biochemical sciences
Date: June 27, 2003
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Wysocka J, Herr W (2003) The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Trends in biochemical sciences 28: 294-304.