Abstract: To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.Keywords: *Aging; Animals; Behavior, Animal; Caenorhabditis elegans/cytology/growth & development/*physiology; Caenorhabditis elegans Proteins/genetics/metabolism; Cell Size; *Electron Transport; Electron Transport Complex I; Electron Transport Complex III/genetics/metabolism; Electron Transport Complex IV/genetics/metabolism; Endoribonucleases/genetics/metabolism; Feeding Behavior; Iron-Sulfur Proteins/genetics/metabolism; Longevity; Mitochondria/*metabolism; Mitochondrial Proton-Translocating ATPases/genetics/metabolism; Movement; NADH Dehydrogenase/genetics/metabolism; NADH, NADPH Oxidoreductases/genetics/metabolism; *Oxygen Consumption; Phenotype; RNA Interference; RNA, Double-Stranded/genetics/metabolism; RNA, Messenger/genetics/metabolism; Receptor, Insulin/genetics/metabolism; Ribonuclease III; Transcription Factors/genetics/metabolism
Journal: Science (New York, N.Y.)
Date: Dec. 10, 2002
Select reference article to upload
Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Rates of behavior and aging specified by mitochondrial function during development. Science (New York, N.Y.) 298: 2398-401.