Authors: Ruiu G; Cassader M; Gambino R; Alemanno N; Demichieli F; Pagano A; Veglia F; Pagano G
Abstract: Apo E phenotype and plasma Tg, Chol, LDL-Chol, HDL-Chol and Apo B levels were determined in a sample of 228 healthy Italian subjects (124 men and 104 women) aged 18-93. The allele frequencies were: epsilon 2 = 0.070; epsilon 3 = 0.829; epsilon 4 = 0.101 (among the lowest values in the literature). Division of the sample into four age groups indicated that epsilon 4 frequency decreased with age to 0 in persons aged over 75. Covariance analysis of the influence of each allele on plasma lipids showed that epsilon 4 was significantly associated with the highest Chol, LDL-Chol and Apo B levels. These data are evidence of the influence of epsilon 4 on Chol metabolism in an Italian population. They also show that its frequency decreases with age.Keywords: Adolescent; Adult; Aged; Aged, 80 and over; Aging/*physiology; *Alleles; Apolipoproteins E/*genetics; Female; *Gene Frequency; Humans; Italy; Lipids/*blood; Male; Middle Aged; Polymorphism, Genetic
Journal: Aging (Milan, Italy)
Date: Aug. 1, 1995
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Ruiu G, Cassader M, Gambino R, Alemanno N, Demichieli F, Pagano A, Veglia F, Pagano G (1995) Apolipoprotein E allele frequencies in an Italian population: relation to age and lipid profile. Aging (Milan, Italy) 7: 185-9.