Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa.

Authors: Miles A; Miller DJ

Abstract: We report the nucleotide sequence of eveC, a cnidarian eve-class homeobox; this is the first homeobox to be identified in any diploblastic organism, and is only the second eve-class in an invertebrate. Similarity between the predicted amino acid sequence of the eveC homeodomain and its insect and vertebrate equivalents was approximately 75-80% but, in the case of eveC, a role in segmentation can be ruled out. Our findings thus support the 'co-option' hypothesis: homeoboxes were an early feature of metazoan genomes, corresponding to the DNA-binding domains of more general transcription factors.

Keywords: Amino Acid Sequence; Animals; *Bacterial Proteins; Base Sequence; Biological Evolution; Cnidaria/*genetics; DNA/genetics; DNA-Binding Proteins/genetics; Drosophila/genetics; *Drosophila Proteins; *Genes, Homeobox; *Homeodomain Proteins; Molecular Sequence Data; Sequence Homology, Nucleic Acid; *Transcription Factors
Journal: Proceedings. Biological sciences / The Royal Society
Volume: 248
Issue: 1322
Pages: 159-61
Date: May 22, 1992
PMID: 1352890
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Citation:

Miles A, Miller DJ (1992) Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa. Proceedings. Biological sciences / The Royal Society 248: 159-61.



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