The catalase -262C/T promoter polymorphism and aging phenotypes.

Authors: Christiansen L; Petersen HC; Bathum L; Frederiksen H; McGue M; Christensen K

Abstract: A low level of the central antioxidant enzyme catalase has been suggested to be a risk factor for diseases influenced by oxidative stress. In this study, we investigated the possible association of the catalase -262C/T polymorphism with survival, physical and cognitive functioning, and a number of oxidative stress-mediated disorders. The study population was 2223 Danish individuals, aged 45-93 years, drawn from three population-based surveys. The results suggest that the catalase -262C/T polymorphism is not associated with either survival, or the majority of the age-related phenotypes investigated. However, our data indicate a statistical significant association of TT homozygosity with improved physical functioning as well as a trend of the T allele conferring an improved general cognitive functioning, although these results did not remain significant after correcting for multiple testing. The results raise the hypothesis that the catalase -262T allele serves as protection against neurodegenerative and physical decline, although replication in other studies is warranted for confirmation of these findings.

Keywords: Aged; Aged, 80 and over; Aging/*genetics; Alleles; Catalase/*genetics; Cognition; Female; Homozygote; Humans; Longevity/genetics; Male; Middle Aged; Oxidative Stress/genetics; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences
Volume: 59
Issue: 9
Pages: B886-9
Date: Oct. 9, 2004
PMID: 15472150
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Citation:

Christiansen L, Petersen HC, Bathum L, Frederiksen H, McGue M, Christensen K (2004) The catalase -262C/T promoter polymorphism and aging phenotypes. The journals of gerontology. Series A, Biological sciences and medical sciences 59: B886-9.


Longevity Variant Associations (p-value):
  • -262C/T

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