Authors: Melzer D
Abstract: Aging shows great heterogeneity between people, with a substantial part attributable to genetic differences. In a candidate gene study across three older populations, polymorphisms in the p16/p15 locus (INK4a/INK4b, CDKN2a/b) were associated with a substantial difference in levels of physical functioning. Recent large-scale genome wide association (GWA) studies for type 2 diabetes and myocardial infarction have also found major variants in this locus, confirming the p16/p15 region as a key aging site. Many other GWA findings are in novel pathways, providing new potential targets for interventions to slow aging.
Keywords: Aging/*genetics; *Genetic Predisposition to Disease; Genome, Human/genetics; Humans; *Polymorphism, Genetic|
Journal: Rejuvenation research Volume: 11 Issue: 2 Pages: 523-6 Date: March 18, 2008 PMID: 18341427 |
Melzer D (2008) Genetic polymorphisms and human aging: association studies deliver. Rejuvenation research 11: 523-6.
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