Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.

Authors: Nebel A; Flachsbart F; Schäfer A; Nothnagel M; Nikolaus S; Mokhtari NE; Schreiber S

Abstract: In a previous study on Sicilian men, an association of the functional polymorphism Asp299Gly in the TLR4 gene was reported with longevity and a reduced risk of myocardial infarction (MI). Here, we sought to confirm the findings in our extensive collection of 273 long-lived men (95-107 years), 606 male early-onset MI patients and 594 appropriate controls from Germany. Despite sufficient statistical power to replicate the findings observed in the South Italians, our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity or MI in German men. Therefore, the previously described associations in Sicilians might reflect either population-specific or potentially false-positive results.

Keywords: Adult; Aged; Amino Acid Substitution; Aspartic Acid/chemistry/genetics; Germany; Glycine/chemistry/genetics; Humans; Longevity/*genetics; Male; Middle Aged; Myocardial Infarction/*genetics; Polymorphism, Genetic; Toll-Like Receptor 4/*genetics
Journal: Mechanisms of ageing and development
Volume: 128
Issue: 5-6
Pages: 409-11
Date: May 12, 2007
PMID: 17493663
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Citation:

Nebel A, Flachsbart F, Schäfer A, Nothnagel M, Nikolaus S, Mokhtari NE, Schreiber S (2007) Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. Mechanisms of ageing and development 128: 409-11.


Lifespan Factors:
  • TLR4 toll-like receptor 4

  • Longevity Variant Associations (p-value):
  • rs4986790 (0.61)

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