The role of p21 in regulating mammalian regeneration.

Authors: Arthur LM; Heber-Katz E

Abstract: The MRL (Murphy Roths Large) mouse has provided a unique model of adult mammalian regeneration as multiple tissues show this important phenotype. Furthermore, the healing employs a blastema-like structure similar to that seen in amphibian regenerating tissue. Cells from the MRL mouse display DNA damage, cell cycle G2/M arrest, and a reduced level of p21CIP1/WAF. A functional role for p21 was confirmed when tissue injury in an adult p21-/- mouse showed a healing phenotype that matched the MRL mouse, with the replacement of tissues, including cartilage, and with hair follicle formation and a lack of scarring. Since the major canonical function of p21 is part of the p53/p21 axis, we explored the consequences of p53 deletion. A regenerative response was not seen in a p53-/- mouse and the elimination of p53 from the MRL background had no negative effect on the regeneration of the MRL.p53-/- mouse. An exploration of other knockout mice to identify p21-dependent, p53-independent regulatory pathways involved in the regenerative response revealed another significant finding showing that elimination of transforming growth factor-beta1 displayed a healing response as well. These results are discussed in terms of their effect on senescence and differentiation.

Journal: Stem cell research & therapy
Volume: 2
Issue: 3
Pages: 30
Date: July 5, 2011
PMID: 21722344
Select reference article to upload


Arthur LM, Heber-Katz E (2011) The role of p21 in regulating mammalian regeneration. Stem cell research & therapy 2: 30.

Lifespan Factors:
  • Cdkn1a Cyclin-dependent kinase inhibitor 1A

  • Update (Admin) | Auto-Update

    Comment on This Data Unit