Authors: Lenzen HJ; Assmann G; Buchwalsky R; Schulte H
Abstract: We determined the frequencies of genetic apolipoprotein E isoforms in 570 survivors of myocardial infarction, all with demonstrable coronary heart disease, as compared with 624 healthy persons. In controls, E-4/E-3 heterozygosity was associated with total cholesterol concentrations of 1985 (SD 364) mg/L and low-density lipoprotein (LDL)-cholesterol concentrations of 1306 (SD 332) mg/L. Significantly lower values, 1811 (SD 312) mg/L and 1121 (SD 274) mg/L, respectively, were observed for E-3/E-2 heterozygous persons. In survivors of myocardial infarction, the respective values were significantly higher than in controls, differing between E-4/E-3 and E-3/E-2 heterozygous patients by 233 and 220 mg/L, respectively. Moreover, E-4/E-3 heterozygosity was accompanied by earlier age of myocardial infarction (48.8 +/- 7.4 years) as compared with E-3/E-2 heterozygosity (53.4 +/- 6.9 years) and E-3/E-3 homozygosity (51.2 +/- 7.7 years). Evidently, apolipoprotein E polymorphism can contribute to total and LDL-cholesterol concentrations in serum, thereby affecting risk of coronary heart disease and myocardial infarction.Keywords: Age Factors; Alleles; Apolipoproteins E/*genetics; Cholesterol, LDL/*blood; Coronary Disease/*blood/genetics; Heterozygote Detection; Humans; Isoelectric Focusing; Male; Middle Aged; Myocardial Infarction/blood/genetics; Phenotype; *Polymorphism, Genetic
Journal: Clinical chemistry
Date: May 1, 1986
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Lenzen HJ, Assmann G, Buchwalsky R, Schulte H (1986) Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. Clinical chemistry 32: 778-81.