Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging

Leukemia. 2011 Aug;25(8):1370-4. doi: 10.1038/leu.2011.98. Epub 2011 May 13.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / pathology*
  • Animals
  • Bone Marrow Cells / pathology*
  • Cellular Senescence
  • Embryonic Stem Cells / pathology*
  • Growth Hormone / genetics
  • Growth Hormone / physiology*
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Like Growth Factor I / physiology*
  • Male
  • Mice
  • Mice, Transgenic
  • Pluripotent Stem Cells / pathology*

Substances

  • Insulin-Like Growth Factor I
  • Growth Hormone