Regulation of SIRT1 in cellular functions: role of polyphenols.

Authors: Chung, Sangwoon; Yao, Hongwei; Caito, Samuel; Hwang, Jae-Woong; Arunachalam, Gnanapragasam; Rahman, Irfan

Abstract: Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular senescence/aging, inflammation-immune function, endothelial functions, and circadian rhythms. Naturally occurring dietary polyphenols, such as resveratrol, curcumin, quercetin, and catechins, have antioxidant and anti-inflammatory properties via modulating different pathways, such as NF-kappaB- and mitogen activated protein kinase-dependent signaling pathways. In addition, these polyphenols have also been shown to activate SIRT1 directly or indirectly in a variety of models. Therefore, activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction. In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli.

Keywords: Adipogenesis; Animals; Apoptosis; Autophagy; Caloric Restriction; Cell Aging; Cell Proliferation; Energy Metabolism; Enzyme Activation/drug effects; Flavonoids/*pharmacology; Humans; Immune System/enzymology; Inflammation/metabolism; Models, Biological; Muscle, Skeletal/physiology; NAD/metabolism; Neoplasms/etiology; Oxidation-Reduction; Oxidative Stress; Phenols/*pharmacology; Poly(ADP-ribose) Polymerases/metabolism; Polyphenols; Sirtuin 1/*metabolism
Journal: Arch Biochem Biophys
Volume: 501
Issue: 1
Pages: 79-90
Date: Sept. 1, 2010
PMID: 20450879
Select reference article to upload


Chung, Sangwoon, Yao, Hongwei, Caito, Samuel, Hwang, Jae-Woong, Arunachalam, Gnanapragasam, Rahman, Irfan (2010) Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys 501: 79-90.

Lifespan Factors:
  • Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)

  • Update (Admin) | Auto-Update

    Comment on This Data Unit