Long-term dynamics of CA1 hippocampal place codes.

Authors: Ziv Y; Burns LD; Cocker ED; Hamel EO; Ghosh KK; Kitch LJ; Gamal AE; Schnitzer MJ

Abstract: Using Ca(2+) imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, as each day the ensemble representation of this environment involved a unique subset of cells. However, cells in the approximately 15-25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.

Journal: Nature neuroscience
Date: Feb. 12, 2013
PMID: 23396101
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Notes:

[http://www.biocompare.com/ife-science-news/131320-stanford-researchers-develop-tool-for-reading-the-minds-of-mice/]



Categories: Aging
Citation:

Ziv Y, Burns LD, Cocker ED, Hamel EO, Ghosh KK, Kitch LJ, Gamal AE, Schnitzer MJ (2013) Long-term dynamics of CA1 hippocampal place codes. Nature neuroscience.



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