Authors: Pearson KJ; Baur JA; Lewis KN; Peshkin L; Price NL; Labinskyy N; Swindell WR; Kamara D; Minor RK; Perez E; Jamieson HA; Zhang Y; Dunn SR; Sharma K; Pleshko N; Woollett LA; Csiszar A; Ikeno Y; Le Couteur D; Elliott PJ; Becker KG; Navas P; Ingram DK; Wolf NS; Ungvari Z; Sinclair DA; de Cabo R
Abstract: A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.Keywords: Age Factors; Aging/*drug effects/genetics/metabolism; Animals; Antioxidants/pharmacology/therapeutic use; Apoptosis/drug effects/physiology; *Caloric Restriction; Cardiovascular System/drug effects/physiopathology; Energy Intake/*genetics; Food Deprivation/physiology; Food, Formulated; Gene Expression Regulation/drug effects/genetics; Inflammation/drug therapy/prevention & control; Longevity/*drug effects/genetics; Male; Mice; Mice, Inbred C57BL; Osteoporosis/drug therapy/prevention & control; Stilbenes/*pharmacology/therapeutic use; Transcription, Genetic/*drug effects/genetics; Treatment Outcome
Journal: Cell metabolism
Date: July 5, 2008
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Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell metabolism 8: 157-68.