Authors: Giannakou, Maria E; Goss, Martin; Junger, Martin A; Hafen, Ernst; Leevers, Sally J; Partridge, Linda
Abstract: Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated the timing of the effect of reduced IIS on life-span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a downstream effector of IIS, in the adult Drosophila fat body, which increased life-span and reduced fecundity of females but had no effect on male life-span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity.
Keywords: Animals; Animals, Genetically Modified; Drosophila Proteins/genetics/*physiology; Drosophila melanogaster/genetics/*physiology; Fat Body/*metabolism; Female; Fertility; Forkhead Transcription Factors; Gene Expression; *Longevity; Male; Transcription Factors/genetics/*physiology|
Journal: Science Volume: 305 Issue: 5682 Pages: 361 Date: July 16, 2004 PMID: 15192154 |
Giannakou, Maria E, Goss, Martin, Junger, Martin A, Hafen, Ernst, Leevers, Sally J, Partridge, Linda (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361.
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