GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER.

Authors: Remolina, Silvia C; Chang, Peter L; Leips, Jeff; Nuzhdin, Sergey V; Hughes, Kimberly A

Abstract: Natural diversity in aging and other life-history patterns is a hallmark of organismal variation. Related species, populations, and individuals within populations show genetically based variation in life span and other aspects of age-related performance. Population differences are especially informative because these differences can be large relative to within-population variation and because they occur in organisms with otherwise similar genomes. We used experimental evolution to produce populations divergent for life span and late-age fertility and then used deep genome sequencing to detect sequence variants with nucleotide-level resolution. Several genes and genome regions showed strong signatures of selection, and the same regions were implicated in independent comparisons, suggesting that the same alleles were selected in replicate lines. Genes related to oogenesis, immunity, and protein degradation were implicated as important modifiers of late-life performance. Expression profiling and functional annotation narrowed the list of strong candidate genes to 38, most of which are novel candidates for regulating aging. Life span and early age fecundity were negatively correlated among populations; therefore, the alleles we identified also are candidate regulators of a major life-history trade-off. More generally, we argue that hitchhiking mapping can be a powerful tool for uncovering the molecular bases of quantitative genetic variation.

Journal: Evolution
Volume: 66
Issue: 11
Pages: 3390-3403
Date: Nov. 1, 2012
PMID: 23106705
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Citation:

Remolina, Silvia C, Chang, Peter L, Leips, Jeff, Nuzhdin, Sergey V, Hughes, Kimberly A (2012) GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER. Evolution 66: 3390-3403.


Study Lifespan Factors:
  • Fhos
  • CG4726
  • CG6041
  • CG6048
  • fs(1)M3 female sterile (1) M3
  • CG6511
  • CG13306
  • CG34426
  • Doc3 Dorsocross3
  • CG5194
  • Tequila
  • CG12004
  • CG12090
  • CG7852
  • CG13917
  • CG12016
  • kst karst
  • Ten-a Tenascin accessory
  • LanB2 Laminin B2
  • CG16711
  • Doc1
  • CG4942
  • Prm Paramyosin
  • CG32022
  • CG12576
  • Rh2 Rhodopsin 2
  • endoA endophilin A
  • CG6184
  • CG6195
  • CG16718
  • fry furry
  • CG34243
  • Cct1 CTP:phosphocholine cytidylyltransferase 1
  • Psa Puromycin sensitive aminopeptidase
  • dro2 drosomycin-2
  • dro4 drosomycin-4


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