Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

Authors: Tettweiler G; Miron M; Jenkins M; Sonenberg N; Lasko PF

Abstract: eIF4E, the mRNA 5' cap-binding protein, is regulated by its binding protein (4E-BP), a downstream target of phosphatidylinositol-3-OH kinase [PI(3)K] signaling. We show that Drosophila 4E-BP (d4E-BP) activity becomes critical for survival under dietary restriction and oxidative stress, and is linked to life span. The Drosophila forkhead transcription factor (dFOXO) activates d4E-BP transcription. We show that ectopic expression of d4E-BP in dFOXO-null flies restores oxidative stress resistance to control levels. Thus, d4E-BP is an important downstream effector of a dFOXO phenotype, and regulation of translation by eIF4E is vital during environmental stress.

Keywords: Aging/genetics/physiology; Animals; Animals, Genetically Modified; Drosophila Proteins/*physiology; Drosophila melanogaster/genetics/*physiology; Eukaryotic Initiation Factor-4E/*metabolism; Longevity/genetics/physiology; Oxidative Stress/*physiology; Starvation/*metabolism
Journal: Genes & development
Volume: 19
Issue: 16
Pages: 1840-3
Date: Aug. 2, 2005
PMID: 16055649
Select reference article to upload


Citation:

Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko PF (2005) Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes & development 19: 1840-3.


Study Lifespan Factors:
  • Thor


  • Update (Admin) | Auto-Update

    Comment on This Data Unit