Authors: Lushchak OV; Gospodaryov DV; Rovenko BM; Glovyak AD; Yurkevych IS; Klyuba VP; Shcherbij MV; Lushchak VI
Abstract: It has recently been demonstrated that as the ratio of protein to carbohydrate (P:C) in the diet declines, life span increases in Drosophila. Here we explored how extremely low dietary ratios of protein to carbohydrate affected longevity and a selection of variables associated with functional senescence. An increase in P:C ratio from 1:57 to 1:20 shortened life span by increasing age-dependent mortality; whereas a further decline in P:C from 1:57 to 1:95 caused a modest decrease in life span. Female flies consuming the 1:20 and 1:38 diets laid more eggs than those consuming the lower P:C diets. Flies fed diets with higher ratios were more resistant to heat stress. Flies consuming the diets with lowest P:C ratios needed more time to restore activity after paralysis. Our study has therefore extended to very low P:C ratios available data demonstrating that dietary P:C ratio affects life span, fecundity and heat stress resistance, with fecundity and heat stress responses showing the opposite trend to life span.
Keywords: *Aging; Animals; Carbohydrates/*pharmacology; Drosophila melanogaster/*growth & development; Female; Fertility/physiology; Life Cycle Stages/*physiology; Longevity/*drug effects/physiology; Male; Proteins/*pharmacology|
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 67 Issue: 2 Pages: 118-25 Date: Nov. 2, 2011 PMID: 22042724 |
Lushchak OV, Gospodaryov DV, Rovenko BM, Glovyak AD, Yurkevych IS, Klyuba VP, Shcherbij MV, Lushchak VI (2012) Balance between macronutrients affects life span and functional senescence in fruit fly Drosophila melanogaster. The journals of gerontology. Series A, Biological sciences and medical sciences 67: 118-25.
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