Authors: Lee KP; Simpson SJ; Clissold FJ; Brooks R; Ballard JW; Taylor PW; Soran N; Raubenheimer D
Abstract: Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein-carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.
Keywords: Animals; *Caloric Restriction; Carbohydrates; Drosophila melanogaster/*physiology; Longevity/*physiology; Proteins|
Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 105 Issue: 7 Pages: 2498-503 Date: Feb. 13, 2008 PMID: 18268352 |
Lee KP, Simpson SJ, Clissold FJ, Brooks R, Ballard JW, Taylor PW, Soran N, Raubenheimer D (2008) Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proceedings of the National Academy of Sciences of the United States of America 105: 2498-503.
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