Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.

Authors: Kaeberlein M; Andalis AA; Liszt GB; Fink GR; Guarente L

Abstract: The SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.

Keywords: Alleles; *Gene Expression Regulation, Fungal; Genes, Fungal/genetics; Histone Deacetylases/*metabolism; Longevity/*genetics; Oligonucleotide Array Sequence Analysis; Osmolar Concentration; Saccharomyces cerevisiae/genetics/*growth & development/metabolism; Saccharomyces cerevisiae Proteins/*metabolism; Silent Information Regulator Proteins, Saccharomyces cerevisiae/*metabolism; Sirtuin 2; Sirtuins/*metabolism; Temperature; Transformation, Genetic
Journal: Genetics
Volume: 166
Issue: 4
Pages: 1661-72
Date: May 6, 2004
PMID: 15126388
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Citation:

Kaeberlein M, Andalis AA, Liszt GB, Fink GR, Guarente L (2004) Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics 166: 1661-72.


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