Authors: Fujii M; Tanaka N; Miki K; Hossain MN; Endoh M; Ayusawa D
Abstract: To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 degrees C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.
Keywords: Aging/genetics; Animals; Caenorhabditis elegans/drug effects/*genetics/physiology; Drug Resistance/*genetics; *Longevity; Models, Animal; Oxidative Stress; Paraquat/*pharmacology|
Journal: Bioscience, biotechnology, and biochemistry Volume: 69 Issue: 10 Pages: 2015-8 Date: Oct. 26, 2005 PMID: 16244463 |
Fujii M, Tanaka N, Miki K, Hossain MN, Endoh M, Ayusawa D (2005) Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans. Bioscience, biotechnology, and biochemistry 69: 2015-8.
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