Authors: Cypser JR; Johnson TE
Abstract: We investigated the life span of spe-10 mutant nematodes. We also tested resistance of spe-10 mutants to ultraviolet (UV) light, heat, and paraquat and examined the relationship between resistance to UV light and the fertility defect of these animals. The spe-10 mutation significantly increased mean life span. Additionally, the mutation significantly increased resistance to both UV light and to heat. Resistance to paraquat was not significantly different from that of wild-type, nor were any dauers formed at 27 degrees C. No significant correlation was found between the UV resistance and the fertility defect, nor was the UV resistance attributable to a hormetic effect. These results reinforce the importance of stress resistance in specifying increased life span and indirectly suggest that this fertility defect is not a direct cause of life span extension.
Keywords: Animals; Caenorhabditis elegans/*genetics/growth & development/*metabolism; Drug Resistance; Fertility; Genes, Helminth/genetics/*physiology; Helminth Proteins/genetics/physiology; Herbicides/pharmacology; Hot Temperature; Longevity/drug effects/*genetics/radiation effects; Mutation/physiology; Oxidative Stress/genetics; Paraquat/pharmacology; Temperature; Ultraviolet Rays|
Journal: Neurobiology of aging Volume: 20 Issue: 5 Pages: 503-12 Date: Jan. 19, 2000 PMID: 10638523 |
Cypser JR, Johnson TE (1999) The spe-10 mutant has longer life and increased stress resistance. Neurobiology of aging 20: 503-12.
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