Authors: Morris JZ; Tissenbaum HA; Ruvkun G
Abstract: A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence. age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision.
Keywords: Amino Acid Sequence; Animals; Caenorhabditis elegans/*enzymology/genetics/physiology; *Caenorhabditis elegans Proteins; Chromosome Mapping; Helminth Proteins/genetics/*physiology; Longevity/*physiology; Molecular Sequence Data; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositols/metabolism; Phosphotransferases (Alcohol Group Acceptor)/genetics/*physiology; Signal Transduction
Journal: Nature Volume: 382 Issue: 6591 Pages: 536-9 Date: Aug. 8, 1996 PMID: 8700226 |
Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-9.
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