Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.

Authors: Williams DS; Cash A; Hamadani L; Diemer T

Abstract: Reduced dietary intake increases lifespan in a wide variety of organisms. It also retards disease progression. We tested whether dietary supplementation of citric acid cycle metabolites could mimic this lifespan effect. We report that oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO/DAF-16, and the energy sensor, AMP-activated protein kinase, indicating involvement of a pathway that is also required for lifespan extension through dietary restriction. These results demonstrate that supplementation of the citric acid cycle metabolite, oxaloacetate, influences a longevity pathway, and suggest a tractable means of introducing the health-related benefits of dietary restriction.

Keywords: AMP-Activated Protein Kinases/genetics/*metabolism; Animals; Caenorhabditis elegans/genetics/*metabolism; Caenorhabditis elegans Proteins/genetics/*metabolism; Forkhead Transcription Factors/genetics/*metabolism; *Longevity; Oxaloacetic Acids/*metabolism; *Signal Transduction
Journal: Aging cell
Volume: 8
Issue: 6
Pages: 765-8
Date: Oct. 2, 2009
PMID: 19793063
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Citation:

Williams DS, Cash A, Hamadani L, Diemer T (2009) Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging cell 8: 765-8.


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