Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans.

Authors: Abbas S; Wink M

Abstract: Epigallocatechin gallate (EGCG) is a major green tea polyphenol with pronounced antioxidative activity. The effects of EGCG on lifespan and stress resistance in wild-type N2 and transgenic strains of Caenorhabditis elegans [ HSP-16.2/GFP, MEV-1(KN1), FEM-1(HC17)] were investigated. The expression of HSP-16.2 (induced by the pro-oxidant juglone) and the intracellular levels of H (2)O (2) were inhibited by EGCG treatment. Daily administration of 220 muM EGCG increased the mean lifespan by 10.14 % and 14.27 % in N2 and FEM-1(HC17) strains, respectively, and 55 muM EGCG increased the mean lifespan in MEV-1(KN1) by 16.11 %. The survival rate was also increased under lethal oxidative stress by 65.05 %. These findings suggest that the increased mean lifespan and stress resistance in C. ELEGANS apparently depend, among other factors, on the antioxidant properties of EGCG.

Keywords: Animals; Antioxidants/*pharmacology; Caenorhabditis/*drug effects/growth & development/metabolism; Caenorhabditis elegans Proteins/antagonists & inhibitors/metabolism; *Camellia sinensis; Catechin/*analogs & derivatives/pharmacology; Free Radical Scavengers/*pharmacology; Genes, Reporter/physiology; Heat-Shock Proteins/antagonists & inhibitors/metabolism; Hydrogen Peroxide/antagonists & inhibitors/metabolism; Longevity; Oxidative Stress/drug effects; Plant Extracts/*pharmacology; Superoxides/antagonists & inhibitors; Tea
Journal: Planta medica
Volume: 75
Issue: 3
Pages: 216-21
Date: Dec. 17, 2008
PMID: 19085685
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Citation:

Abbas S, Wink M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta medica 75: 216-21.


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