Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.

Authors: Gallo, Marco; Park, Donha; Riddle, Donald L

Abstract: The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity.

Keywords: Animals; Anion Transport Proteins/genetics/metabolism; Caenorhabditis elegans/*genetics/*metabolism; Caenorhabditis elegans Proteins/genetics/metabolism; Energy Metabolism/genetics; Gene Knockdown Techniques; Gene Knockout Techniques; *Genes, Helminth; *Genes, Mitochondrial; Longevity/*genetics/*physiology; Mitochondria/genetics/metabolism; Mutation; Oxidative Stress; Reactive Oxygen Species/metabolism

Journal: Mech Ageing Dev Volume: 132 Issue: 10 Pages: 515-8 Date: Sept. 3, 2011 PMID: 21884719

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Citation:

Gallo, Marco, Park, Donha, Riddle, Donald L (2011) Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. Mech Ageing Dev 132: 515-8.

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