The best practice is to always start using the common denominators of both. In such a conversion from a simple Markdown entry into a full reST data entry can occur instantly.
Common inline markup is:
Mark *italic text* with one arterisk, **bold text** with two. For ``monospaced text``, use two "backquotes" instead.
Mark italic text with one arterisk, bold text with two. For monospaced text, use two "backquotes" instead.
A normal paragraph ending with :: will flow and be word-wrapped:
If the next paragraph is indented by four or more spaces it will be monospace, without flow (or even wrapping in some non-printing cases.) Multiple paragraphs like this, are possible, as long as they are all intended by the same amount.