Long non-coding RNA

Created on Dec. 1, 2012, 12:14 a.m. by Hevok & updated by Hevok on May 2, 2013, 4:57 p.m.

Long non-coding RNAs (lncRNAs) are transcripts that do not encode a protein gene product and are longer than 200 nucleotides in length. They compromise essential components of multiple aspects of gene regulation, such as recruitment of histone and chromatin modifying complexes, transcription factors recruitment and RNA processing [Qureshi et al. 2010]. lncRNA are also required for genomic imprinting. 14 novel putative lncRNAs are differentially expressed in rat brain during aging [Wood et al. 2012]. Activation of the heat-shock transcription factor 1 (HSF1) requires a lncRNA designated heat-shock RNA 1 (HSR1) [Shamovsky et al. 2006].

References

Qureshi IA, Mattick JS, Mehler MF. Long non-coding RNAs in nervous system function and disease. Brain research. 1338, 20–35 (2010).

Wood SH, Craig T, Li Y, Merry B, de Magalhaes JP. Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. Age (Dordr). (2012).

Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 440(7083), 556–560 (2006).

lncRNA.jpg

Tags: expression, ncRNA
Parent: Aging

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