Inactivating miRNA Biogenesis in Adults Speeds up Aging

Created on Nov. 19, 2012, 12:50 a.m. by Hevok & updated by Hevok on May 2, 2013, 4:57 p.m.

Inactivation of DGCR8/pash-1 in nematode reduces lifespan apparently due to accelerated aging. This intervention abrogates (lin-14 mutation and jnk-1(OE)) and suppresses (eat-2 and glp-1 mutants) several lifespan extending interventions, but not that conferred insulin-like signalling inhibition (daf-2 mutant) [23097426].

It is astonishing that even a temporally (just a day) inactivation of pash-1 (i.e. miRNA biogenesis) dramatically reduces the lifespan.

Assuming that miRNA normally silences aging genes and then these aging genes become ectopic expressed ( i.e. pash-1 inactivation) they subsequently program the animal to be at a later age, before they can be silenced again.

Another explanation might be that something gets non-harmonic in this mutant animals and can not be restored.

Protein_DGCR8_PDB_1x47.png
miRNA-biogenesis.jpg

Tags: microRNA, lifespan
Categories: News
Parent: Aging

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