Immune System

Created on Dec. 21, 2012, 6:14 p.m. by Hevok & updated by Hevok on May 2, 2013, 4:54 p.m.

The Immune System consist of the primary lymphoid organs (bone marrow and thymus) as well as secondary lymphoid organs (spleen, lymph nodes, peripheral lymphoid tissues).

All these parts and cells, composing them undergo profound negative effects with Aging:

  • Hematopoietic stem cells dysfunction
  • Thymus atrophy
  • T-Lymphocyte dysfunction
  • Immune response impairment

Therefore, the emergence of immune disorders in Aging is explained by several Factors, including thymus dysfunction, decrease in the proportion and function of naive T cells, and so forth [22533440].

Search for the blood plasma factors which could induce aging.

Investigate lymphoid niche aging: stromal cell functions, extracellular matrix formation, its influences on lymphoid cells activity.

Characterize age-related changes in the stromal cells of spleen, which compose T-cell niche.

Investigate cell migration during heterochronic parabiosis to understand the way of immune system aging.


Tags: immunology, organ system
Categories: News
Parent: Tissues
Children: Immune System Rejuvenation, T-Cell

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