The Immune System consist of the
primary lymphoid organs (bone marrow and thymus) as well as
secondary lymphoid organs (spleen, lymph nodes, peripheral lymphoid tissues).
All these parts and cells, composing them undergo profound negative effects with Aging:
Search for the blood plasma factors which could induce aging.
Investigate lymphoid niche aging: stromal cell functions, extracellular matrix formation, its influences on lymphoid cells activity.
Characterize age-related changes in the stromal cells of spleen, which compose T-cell niche.
Investigate cell migration during heterochronic parabiosis to understand the way of immune system aging.