Change - Exercise

Created on Dec. 24, 2012, 10:17 p.m. by Hevok & updated on Feb. 12, 2013, 8:40 p.m. by Hevok

Exercise is any bodily activity that enhances or maintains physical fitness and overall health/well-being. Give mice a running while, and they will run from 3 to 7 miles every night. It seems to let their brains retain their ability to generate nerve cells. Steady exercise reduces blood levels of various pro-inflammatory molecules whose concentrations typically rise as we age [http://stanmed.stanford.edu/2011fall/article9.html]. ¶
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Exercise is the safest and much more socially acceptable way to delay Aging, compared to Dietary Restriction. Just like Dietary Restriction, Exercise has at least 10 overlapping mechanisms of action: ¶
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1. AMPK activation ¶
2. mTOR inhibition ¶
3. PGC-1a activation ¶
4. Autohagy activation ¶
5. Proteasome activation ¶
6. FOXO3a translocation to nucleus ¶
7. Lowering mitochondrial baseline ROS ¶
8. ROS-mediated Nrf2 translation to the nucleus and turning on ARE genes ¶
9. hypoxia induced HIF-1 translocation to the nucleus, and turning on the latitude response elements ¶
10. SIRT1,2,3 and 4 mediated deacetylation of multiple proteins ¶
11. reduced epigenetic drift ¶
12. DNA repair activation ¶
13. Klotho pathway activation ¶
14. Surprising counter-intuitive effect on hGH and downstream IGF-1 (increased, not decreased) ¶
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These benefits far outweigh the negative effects of NF-kB activation, norepinephrine output from the adrenal gland, glucocorticoid output from the adrenal gland