Change: Brain Aging

created on Dec. 22, 2012, 2:07 p.m. by Hevok & updated on Dec. 24, 2012, 4:02 p.m. by Hevok

Brain Aging often underlies cognitive decline and is a major risk factor for neurodegenerative conditions such as Alzheimer's and Parkinson's disease. Mental health is a major concern of aging adults [15190254].

DNA damage may reduce the expression of selectively vulnerable genes involved in learning, memory, and neuronal survival. After the age of 40 years the prefrontal cortex exhibits a reduction in the expression of genes with central role in synaptic plasticity, vesicular transport and mitochondrial function, followed by induction of stress response, antioxidant and DNA repair genes. There is a markedly increase of DNA damage in the promoters of genes with reduced expression. These gene promoters are selectively damaged by oxidative stress in cultured human neurons and exhibit base-excision DNA repair [15190254].

Dietary Restriction (DR) may delay brain senescence and prevent neurodegeneration. In rhesus monkey, DR decreases brain autrophy, brain iron accumulation, preserved motor performance and increased lifespan [23082321; 20541839]. DR also improves the memory function of elderly humans [19171901].

It may be possible to rejuvenate aging brains with as-yet-unidentified factors circulating in young blood [].


Tags: aging, signatures
Categories: News
Parent: Tissues

Comment: Added paragraph on rejuvenating via systemic factors.

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