Change: Metabolic Signature Predicts Biological Age

created on Nov. 8, 2012, 2:34 p.m. by Hevok & updated on Nov. 8, 2012, 2:34 p.m. by Hevok

Metabolic profiling of 117 wild-type mice of different genetic backgrounds revealed a robust metabolomic signature and metabolomic score that predicts the age of mice. telomerase-deficient mice have a short lifespan and their metabolomic score predicts older ages as they are. In contrast, mice that over-express telomerase and live longer have a metabolic score that corresponds to younger ages. Telomerase reactivation late in life by TERT based gene therapy significantly reverted the metabolic profile of old mice to that of young mice [].

Within this signature there are basically changes mostly in lipid homeostasis and one-carbon metabolism. So the question arises which metabolites are most strongly associated with a biological young state and why are they?


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