Denigma | Articles & Research

@hevok • November 7, 2026 • ⏱️ 8 min read • 1677 words Aging Rejuvenation Immunosenescence mRNA Therapy

Immune Rejuvenation via mRNA Thymic Factors — Liver as Thymus Substitute

> TL;DR: In Nature 2026, MIT / Broad researchers transiently repurposed the liver to restore aged immunity. mRNA-LNPs encoding DLL1, FLT3L, IL-7 (DFI)...

Read article →

@hevok • November 7, 2026 • ⏱️ 9 min read • 1734 words Aging Gerotherapeutics Metabolism Epigenetic Clocks

GLP-1s as Gerotherapeutics — Semaglutide Slows DunedinPACE by 9%

> TL;DR: In 2026, GLP-1 receptor agonists crossed from metabolic drugs to gerotherapeutics. A randomized, double-blind, placebo-controlled analysis in...

Read article →

@hevok • November 5, 2026 • ⏱️ 7 min read • 1340 words Aging Rejuvenation Epigenetic Reprogramming Stem Cells

Direct Blood-to-Brain Rejuvenation - 60 Years Rewound in a Dish

> TL;DR: In October 2026, Bonn researchers directly converted red blood cell precursors from an 80-year-old donor into induced neural stem cells with a...

Read article →

@hevok • November 4, 2026 • ⏱️ 5 min read • 994 words Article News Aging Research

ER-100: First Human Trial of Partial Epigenetic Reprogramming (OSK)

On January 28, 2026, the FDA cleared the first-ever human trial of a partial epigenetic reprogramming therapy. On June 9, 2026, Life Biosciences dosed the...

Read article →

@hevok • November 2, 2026 • ⏱️ 6 min read • 1267 words Aging Transposable Elements Gerotherapeutics Ontology

Revisiting Transposable Elements: From Denigma Hypothesis (2013) to Human Gerotherapeutics (2026)

> TL;DR: In 2013 Denigma predicted that HIV reverse transcriptase inhibitors could suppress LINE-1 retrotransposons for anti-aging effects. In 2026, a...

Read article →

@hevok • April 25, 2025 • ⏱️ 1 min read • 16 words

New Denigma

New version of Denigma, the Digital Deciphering Machine is being launched.

Read article →

@antonkulaga • December 7, 2013 • ⏱️ 5 min read • 1019 words News reST

Biogerontology 101

The main challenge of aging activism is a gap between aging researchers and people interested in longevity and radical lifespan extension. Lack of...

Read article →

@hevok • October 11, 2013 • ⏱️ 1 min read • 129 words News

Gerontology

The Gerontology Ontology (the Ontology for Aging and Longevity, GERO) is a mid-level ontology representing aging-related phenomena from the molecular and...

Read article →

@hevok • October 4, 2013 • ⏱️ 2 min read • 406 words

Colombia

Abogamos por el desarrollo de una longevidad saludable para toda la población mediante investigación científica, salud pública, promoción y activismo...

Read article →

@hevok • October 4, 2013 • ⏱️ 2 min read • 303 words

Israel

מניפסט ILA האיחוד הבינלאומי למען אריכות החיים. אנו דוגלים בקידום אריכות ימים בריאה לכלל האוכלוסייה באמצעות מחקר מדעי, בריאות הציבור ופעילות חברתית. אנו...

Read article →