Denigma

Heterozygous Gh1 anti-sense transgene

Species: Norway rat (Taxid: 10116)
Factor: Gh1
Manipulation: Loss-of-Function, Mutation, Anti-Sense Transgene
Effect:

Animals carrying a single copy of an anti-sense Gh1 transgene (tg/-) live on average 7-10% longer. tg/- animals are dwarfs and exhibit reduced levels of serum IGF1 [12057928].

Mean: +7 to +10

References:
  • 12057928: Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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