Denigma

CDC25 mutation

Species: Budding yeast (Taxid: 4932)
Factor: CDC25
Manipulation: Loss-of-Function, Mutation
Effect:

The CDC25-10 allele extends mean and maximum replicative lifespan by 34% and 18%, respectively, at 30 degree Celsius. cdc25-10 mutants have an extended replicative lifespan under AL. Growth on 0.5% glucose restriction does not further extend replicative lifespan of cdc25-10 mutants. CDC25 null mutant is not viable. CDC25 appears to act in the same genetic pathway as SIR2 and NPT1 and is suggested to be genetic model of DR [11000115].

Mean: +34
Maximum: +18

References:
  • 11000115: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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