Denigma

DATS treatment

Species: Fruit fly (Taxid: 7227)
Factor: DATS
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment with 5-10 μM DATS increases lifespan even when treatment is started during young adulthood. DATS increases the lifespan of daf-2 and daf-16 mutants, but not that of eat-2 mutants.

DATS treatment leads to the induction of the skn-1 target gene gst-4 and this induction is dependent on skn-1. DATS effect on lifespan is dependent on skn-1 activity in both intestine and ASI neurons [21296648].


References:
  • 21296648: The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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