Denigma: Intervention

Brca1 deletion

Species: House mouse (Taxid: 10090)
Factor: Brca1
Manipulation: Loss-of-Function, Mutation, Deletion
Effect:

Deletion of Brca1 causes senescence in mutant embryos and cultured cells and tumorigenesis and signs of premature aging in adults [12533509]. Brca1 heterozygous seem to have shortened lifespan with 70% of tumor incidence. Lymphoma, but not ovarian and mammary gland tumors, occurs commonly in these animals. After a whole-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3-5-fold higher incidence to ovarian tumors, but not lymphoma, when compared with Brca1(+/+) mice [17420720].

References:

17420720: Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

12533509: Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

Aging Relevance Analysis/Source:

GenAge